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The Kansas City Chiefs are on an upward trajectory Ronnie Lott Jersey , their blistering start spearheaded by a young, transcendent quarterback in Patrick Mahomes who is already setting NFL records.The San Francisco 49ers are the opposite in every way.Not only were they soundly beaten in a 38-27 loss at Arrowhead Stadium on Sunday, trailing at one point by four touchdowns, they also lost their own franchise quarterback when Jimmy Garoppolo was carted off in the closing minutes with what appears to be a season-ending knee injury.49ers coach Kyle Shanahan said the team will know more Monday, when Garoppolo has another round of tests in San Francisco. But he acknowledged late Sunday that the injury appears to be an ACL."Any time you lose your starting quarterback," Shanahan said, "that's a big deal."The 49ers (1-2) signed Garoppolo to a five-year, $137.5 million contract earlier this year after he led them to five consecutive wins to cap last season. And despite some turnover problems the first two weeks he had been pretty good, throwing a pair of touchdown passes against Kansas City.Everything turned in the fourth quarter, though, when Garoppolo scrambled toward the sideline. His left knee buckled as he cut back, rather than step safely out of bounds, and Chiefs cornerback Steven Nelson delivered a wicked shoulder-to-shoulder shot for good measure.C.J. Beathard wound up entering the game, threw a touchdown pass that was wiped out by offensive pass interference, and never got to take another snap as the Chiefs put the game away.His next snap will probably be the first one next week against the Chargers."It' definitely a blow. He's a great quarterback and obviously a great leader," said Beathard, who started five games last season before Garoppolo arrived in a trade with New England."Just keep these guys together. Keep leading them," he said. "We had a lot of injuries today, not just Jimmy. A lot of guys went down today. Just a matter of keeping everybody healthy next week."Meanwhile, the Chiefs (3-0) couldn't be happier with the performance of their young quarterback.Mahomes threw for 314 yards and three touchdowns against San Francisco, giving him 13 on the year without an interception. That broke Peyton Manning's NFL record for the first three weeks of a season.Perhaps most impressive, though, was the way Mahomes spread the wealth. He targeted 11 different receivers, connected with eight and found three with touchdown throws."Pat lives for these moments," said Chiefs wide receiver Chris Conley, who had one of the TDs. "I think he excels when the lights are on, and in front of big crowds. I think he's right at home. I think he's in his element. I think he's still growing into his role as the starting quarterback here, and we've just got to keep working with him and growing as well."As the 49ers and Chiefs roll into next week, here are five takeaways from Sunday:PENALTY PROBLEMS: The 49ers were whistled for 14 penalties for 147 yards, and that doesn't count a couple instances of off-setting flags and where they were penalized twice on the same play. That yardage total is substantial chunk of the 408 yards of total offense managed by San Francisco.SACK ATTACK: The Chiefs only had two sacks through the first two weeks, but Justin Houston had two by himself on Sunday. Dee Ford also had a sack before leaving with a groin injury Tom Rathman Jersey , and Allen Bailey had another to help stop San Francisco's final drive of the game.RUN, RUN, RUN: San Francisco rallied on the legs of Matt Breida, who led the NFL in rushing coming into the game and had 90 yards on 10 carries, and Alfred Morris, who had 14 carries for 67 yards and a touchdown. With uncertainty at quarterback, the 49ers' ground game will be even more important.SPEAKING OF RUN: Chiefs running back Kareem Hunt, last year's rushing champ, had his first two TD runs this season. He only gained 44 yards on 18 carries against San Francisco, but many of them came in the closing minutes, when he picked up two first downs to put the game away.MORE INJURY NEWS: The 49ers lost cornerback Richard Sherman to a calf injury, safety Adrian Colbert to an ankle injury, linebacker Reuben Foster on a tackle and backup defensive back Tarvarius Moore to a wrist injury. Throw in a shoulder injury to safety Jaquiski Tartt that kept him on the inactive list and San Francisco has plenty of injury problems on defense. Things are winding down as the NFL postseason is coming to its end. There are only three games left - the NFC and AFC Championship games this weekend and the Super Bowl two weekends from now - and, of the matchups we have, it’s safe to say that no matter who wins we will still have a quite the show in Atlanta. As the season comes to a close we will start seeing more and more news posted about the the upcoming draft and it seemingly all starts this weekend with the East/West Shrine game and the NFLPA Collegiate Bowl. Below you will find some prospects to watch for the Shrine Game. San Francisco will have a keen interest in this game as there are several names to keep an eye on as the morning progresses. Here are some highlights and things to look forward to while you try and fill your time as you await Sunday’s NFL games.How to watchTime: Noon (3 p.m. ET)Location: Tropicana Field in St. Petersburg, FloridaTelevised: NFL NetworkRadio: SiriusXM NFL Channel 88 East-West Shrine Game Tampa Bay “Flagship Station” is “Sports Talk Florida” WHBO 1040 AM Internationally, the game will be found on a “Listen Live” link on this website, and on the Tunein and SiriusXM Apps.Greg ValerioKeeSean Johnson, WR, No. 2 (West) - Fresno StateHeight: 6011 | Weight: 204 | 40 time: 4.572018 Stats: 95 receptions, 1340 yards, 14.1 average yards per catch, and 8 touchdownsKeeSean Johnson is not a freakishly athletic wide receiver with explosive game breaking speed. He is, however, a good-sized dependable chain-moving receiver with consistent high production and a strong work ethic showcasing his capacity to improve each year. Johnson is a fluid route runner (runs crisp) with a smoothness and sound technique to his game. He showcases great explosion off the line and displays nice bend on breaks coming out quickly with great suddenness and decent burst. He flashes strong reliable hands and is a natural pass catcher with excellent ball skills. Johnson wins in intermediate routes and although he does not possess elite speed, he does win deep match-ups with technique, length, body control, superb ball skills, and high-pointing the catch with great athleticism. Johnson is the type of prospect one can find deep in the draft adding tremendous value at the next level. Cody Thompson, WR Patrick Willis Jersey , No. 25 (West) - ToledoHeight: 6014 | Weight: 200 | 40 time: 4.542018 Stats: 48 receptions, 647 yards, 13.5 average yards per catch, and 10 touchdownsCody Thompson is a fluid playmaker with good speed and quickness, strong reliable hands (natural pass catcher), solid ball skills, and is explosive after the catch running with toughness always spinning for the extra yards. A former high school basketball star athlete, Thompson displays impressive strength and toughness as a receiver (not afraid to take a hit or deliver one), is a fluid and crisp route runner with a smoothness (double moves are on point) to his game showcasing great bend on breaks popping out quickly with great athleticism, nice footwork, quickness, and decent burst. The former high school quarterback displays terrific vision and awareness taking advantage of his high football IQ and savviness utilizing subtle movements to create separation, locates holes on defenses, and works his way back to the quarterback. A willing blocker, Thompson also displays great effort in blocking with solid technique. Next level athleticism and lack of elite speed will limit his opportunities at the next level; however, top notch route running, premier hands, and a solid work ethic will find him a home in the NFL.Alex EisenJordan Brailford, DE, No. 94(East) - Oklahoma StateHeight: 6’3” | Weight: 250 | 40 Time: 4.952018 Stats: 54 Tackles, 16 Tackles for a loss, 9 Sacks, 1 Forced Fumble, 1 Batted PassThe versatile athlete out of Oklahoma State was a big factor in the Cowboy’s defense this season. Brailford played at both defensive end spots and at three linebacker spots while he was at Oklahoma State in his collegiate career.. Has good size and measurables for the next level. He has the ability to reach on the pass rush, and can line up in a 3-point stance or as a stand-up outside linebacker. Demonstrates good burst and a quick first step off the snap. At times Brailford can be off balance, and can be one dimensional on rushes against the pass. While I do like his straight-line speed in pass rushing situations, his lateral quickness leaves a little be desired. On tape, Brailford demonstrates his ability to utilize active swipes against blockers. Overall, there is a lot to like about Brailford. I like his ability to play multiple positions on the field. An ability I believe most teams are looking for at the pro level. At the moment I see Brailford as an early day three pick who could potentially sneak into the backend of the second day of the 2019 NFL Draft.Markus Jones, DE, No. 43 (West) - Angelo StateHeight: 6’3” | Weight: 255 | 40 Time: 4.892018 Stats: 84 tackles Jerry Rice Jersey , 36.5 tackles for a loss, 17.5 sacks, 17 quarterback hurries, 4 forced fumblesComing from a small school environment, there isn’t too much buzz or national media attention surrounding Markus Jones. However, he has made quite the name for himself and has put himself in prime position to be drafted in April. Jones comes off strong along the edge, and attacking on point, against blockers. Jones caused a massive amount of disruption this season in the opponent’s backfield. Jones was often required double-team coverage which allowed his teammates to make positive contributions along the defensive line. Jones demonstrates good bend and the ability to use multiple moves against blockers along the line of scrimmage. His ability to bull rush is consistent. Jones demonstrates good lateral speed and defends the edge well against ball carriers. Jones’ stats are off the charts, even playing in the second division in football. His invitation to the shrine game wasn’t by accident. Jones is one of those small school prospects to keep a close eye on throughout the draft process. His draft projection is difficult to project at this point, however, his arrow is pointing up. Josh EcclesDerick Roberson, DE, No. 49 (West) - Sam Houston StHeight: 6040 | 250 lbs | 40 time: 4.762018 stats: 68 tackles, 15 sacks, 2 PD, 5 FFAs a pass rusher, Derick Roberson has a few different moves and can get off the ball so quickly that opposing offensive linemen can sometimes struggle just to get a hand on him, at other times using a little hesitation move or shoulder dip to turn the corner and get to the quarterback. There’s also evidence of a spin move and a club move that can keep offensive linemen from getting their hands into his body, as well as an outside-inside move that would make Von Miller proud. Overall, Roberson has all of the athletic ability necessary to be a good weakside defensive end in high school if he can hone his jump off the ball and continue to refine the variety of pass-rushing moves that his film proves he does have in his arsenal. If Roberson can maximize his significant potential, he could be an all-conference type of player. Roberson had 123 tackles, 23 sacks, seven forced fumbles and eight passes defensed in three seasons at Sam Houston State, with 68 tackles, 15 sacks and five forced fumbles as a senior. The 49ers are one of four teams reported to have met with Roberson, among with the Bills, Browns, and Colts.